{"id":1682,"date":"2024-12-12T23:37:59","date_gmt":"2024-12-12T23:37:59","guid":{"rendered":"https:\/\/blogschapman.wpenginepowered.com\/gci\/2024\/12\/12\/dr-aracely-acevedo-the-bckdk-inhibitor-bt2-is-a-chemical-uncoupler-that-lowers-mitochondrial-ros-productions-and-de-nova-lipogenesis\/"},"modified":"2026-07-20T06:02:42","modified_gmt":"2026-07-20T06:02:42","slug":"dr-aracely-acevedo-the-bckdk-inhibitor-bt2-is-a-chemical-uncoupler-that-lowers-mitochondrial-ros-productions-and-de-nova-lipogenesis","status":"publish","type":"post","link":"https:\/\/blogs.chapman.edu\/gci\/2024\/12\/12\/dr-aracely-acevedo-the-bckdk-inhibitor-bt2-is-a-chemical-uncoupler-that-lowers-mitochondrial-ros-productions-and-de-nova-lipogenesis\/","title":{"rendered":"Dr. Aracely Acevedo: The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS productions and de nova lipogenesis"},"content":{"rendered":"<p>At our 2024 GCI Postdoctoral Showcase, Postdoctoral Fellow Aracely Acevedo presented a poster about the BCKDK inhibitor being a chemical uncoupler. To learn more about her research, reach out to Dr. Acevedo at aracevedo@chapman.edu.<\/p>\n<p><span data-olk-copy-source=\"MessageBody\">ABSTRACT:<em> The objective of this study, conducted at UCLA, was to investigate alternative molecular mechanisms by which BT2 may confer cardioprotection and protect from metabolic disease. We hypothesized that BT2 is a mitochondrial uncoupler based on its chemical structure as a lipophilic weak acid. We demonstrate BT2 is a mitochondrial uncoupler via measurements in respirometry, membrane potential, patch-clamp electrophysiology, fatty acid oxidation and synthesis, and superoxide production. \u00a0The data suggests BT2 may exert some of its cardioprotective effects and protection from metabolic disease via mitochondrial uncoupling.<\/em><\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1684\" src=\"https:\/\/blogs.chapman.edu\/gci\/wp-content\/uploads\/sites\/70\/2024\/11\/Aracely_Acevedo_Chapman_University_GCI_Poster_final_2024Nov_page-0001.jpg\" alt=\"\" width=\"580\" height=\"435\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>At our 2024 GCI Postdoctoral Showcase, Postdoctoral Fellow Aracely Acevedo presented a poster about the BCKDK inhibitor being a chemical [&hellip;]<\/p>\n","protected":false},"author":5302,"featured_media":1744,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center 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