{"id":1850,"date":"2024-06-27T08:52:51","date_gmt":"2024-06-27T15:52:51","guid":{"rendered":"https:\/\/blogschapman.wpenginepowered.com\/pharmacy\/2024\/06\/27\/national-institute-on-aging-awards-grant-to-dr-rachita-sumbria-for-alzheimers-disease-theraputics\/"},"modified":"2024-06-27T08:52:51","modified_gmt":"2024-06-27T15:52:51","slug":"national-institute-on-aging-awards-grant-to-dr-rachita-sumbria-for-alzheimers-disease-theraputics","status":"publish","type":"post","link":"https:\/\/blogs.chapman.edu\/pharmacy\/2024\/06\/27\/national-institute-on-aging-awards-grant-to-dr-rachita-sumbria-for-alzheimers-disease-theraputics\/","title":{"rendered":"National Institute on Aging Awards Grant to Dr. Rachita Sumbria for Alzheimer's Disease Therapeutics"},"content":{"rendered":"
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\"\"<\/a>Dr. Rachita Sumbria<\/a>, an associate professor at Chapman University’s School of Pharmacy<\/a>, has been awarded an NIH R01 grant from the National Institute on Aging, receiving $1.71 million over the next 5 years for research on Alzheimer\u2019s disease (AD) therapeutics. This project is founded on data from her lab’s earlier successes in modifying erythropoietin (EPO) to cross the blood-brain barrier (BBB) with promising results in treating AD.<\/p>\n

EPO’s ability to modulate AD-related pathways and its neuroprotective effects provide the rationale for its development, although its limited BBB penetration and hematopoietic side effects pose challenges. The proposed solution involves fusing EPO with a monoclonal antibody (MAb) against the transferrin receptor (TfR) to facilitate BBB penetration and reduce side effects.<\/p>\n

The funds will be used to conduct dose-escalation and safety studies in various AD models, and to investigate the molecular pathways modulated by TfRMAb-EPO, building on prior NIH R21-funded proof-of-concept studies. Preliminary data indicate that this BBB-penetrating EPO has better therapeutic and hematologic indices than EPO alone. EPO\u2019s neuroprotective effects and ability to modulate AD-related pathways justify its development, despite challenges like limited BBB penetration and hematopoietic side effects. The findings may establish a clinically feasible method for sustainable EPO delivery to the AD brain.<\/p>\n

The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.<\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Dr. Rachita Sumbria, an associate professor at Chapman University’s School of Pharmacy, has been awarded an NIH R01 grant from 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