{"id":1954,"date":"2024-10-07T08:18:35","date_gmt":"2024-10-07T15:18:35","guid":{"rendered":"https:\/\/blogschapman.wpenginepowered.com\/pharmacy\/2024\/10\/07\/dr-rachita-sumbria-awarded-nih-r21-grant-to-investigate-the-impact-of-obesity-on-alzheimers-disease-progression\/"},"modified":"2024-10-07T08:18:35","modified_gmt":"2024-10-07T15:18:35","slug":"dr-rachita-sumbria-awarded-nih-r21-grant-to-investigate-the-impact-of-obesity-on-alzheimers-disease-progression","status":"publish","type":"post","link":"https:\/\/blogs.chapman.edu\/pharmacy\/2024\/10\/07\/dr-rachita-sumbria-awarded-nih-r21-grant-to-investigate-the-impact-of-obesity-on-alzheimers-disease-progression\/","title":{"rendered":"Dr. Rachita Sumbria Awarded NIH R21 Grant to Investigate the Impact of Obesity on Alzheimer&#039;s Disease Progression"},"content":{"rendered":"<p><a href=\"https:\/\/blogs.chapman.edu\/pharmacy\/wp-content\/uploads\/sites\/65\/2024\/10\/5B7559B9-06A6-45B2-B910-90578DA2461D_1_105_c.jpeg\" rel=\"attachment wp-att-1983\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1983 alignleft\" src=\"https:\/\/blogs.chapman.edu\/pharmacy\/wp-content\/uploads\/sites\/65\/2024\/10\/5B7559B9-06A6-45B2-B910-90578DA2461D_1_105_c.jpeg\" alt=\"\" width=\"276\" height=\"184\" srcset=\"https:\/\/blogs.chapman.edu\/pharmacy\/wp-content\/uploads\/sites\/65\/2024\/10\/5B7559B9-06A6-45B2-B910-90578DA2461D_1_105_c.jpeg 1086w, https:\/\/blogs.chapman.edu\/pharmacy\/wp-content\/uploads\/sites\/65\/2024\/10\/5B7559B9-06A6-45B2-B910-90578DA2461D_1_105_c-300x200.jpeg 300w, https:\/\/blogs.chapman.edu\/pharmacy\/wp-content\/uploads\/sites\/65\/2024\/10\/5B7559B9-06A6-45B2-B910-90578DA2461D_1_105_c-1024x683.jpeg 1024w, https:\/\/blogs.chapman.edu\/pharmacy\/wp-content\/uploads\/sites\/65\/2024\/10\/5B7559B9-06A6-45B2-B910-90578DA2461D_1_105_c-768x512.jpeg 768w\" sizes=\"auto, (max-width: 276px) 100vw, 276px\" \/><\/a><\/p>\n<p style=\"font-weight: 400\">Associate Professor Dr. <a href=\"https:\/\/www.chapman.edu\/our-faculty\/rachita-sumbria\" target=\"_blank\" rel=\"noopener noreferrer\">Rachita Sumbria<\/a> has been awarded a new R21 grant from the <a href=\"https:\/\/www.nia.nih.gov\/\" target=\"_blank\" rel=\"noopener noreferrer\">National Institute on Aging<\/a> (NIA).<\/p>\n<p style=\"font-weight: 400\">The grant, \u201cThe impact of obesity-induced hepatic amyloid beta dysregulation on Alzheimer\u2019s disease pathology,\u201d focuses on understanding obesity&#8217;s effect on the liver&#8217;s regulation of amyloid beta, a protein associated with Alzheimer&#8217;s disease (AD), and its impact on the brain. The research is a collaborative effort between Dr. Sumbria and Dr. Han from the Keck Graduate Institute.<\/p>\n<p style=\"font-weight: 400\">Dr. Sumbria\u2019s lab will receive $216,701 of the total $405,849 grant to investigate the relationship between obesity and the liver-brain axis in Alzheimer&#8217;s to potentially identify new therapeutic strategies for this devastating disease. &#8220;Alzheimer\u2019s is largely considered a disease of the brain, however, Chapman University\u2019s work and that of others show that liver injury may be a significant contributor to the disease. This R21 grant is an opportunity to further understand the complexity of Alzheimer&#8217;s disease from the perspective of the liver and how factors like obesity can influence its progression,&#8221; said Dr. Sumbria.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-1985 alignright\" src=\"https:\/\/blogs.chapman.edu\/pharmacy\/wp-content\/uploads\/sites\/65\/2024\/10\/IMG_7339.jpeg\" alt=\"\" width=\"299\" height=\"339\" \/><\/p>\n<p style=\"font-weight: 400\">Some of Dr. Sumbria\u2019s previous research that will support this ongoing pursuit to understand\u00a0 AD include \u201c<a href=\"https:\/\/nam11.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F37298443%2F&amp;data=05%7C02%7Coaconnell%40chapman.edu%7C2b95916a203043b3d2d008dce6eb67f3%7C809929af2d2545bf9837089eb9cfbd01%7C0%7C0%7C638639145939708931%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&amp;sdata=Avb5tGENE8Vaer71zH%2FzwWNQ%2FosiqCrkGBGv0gNLYkA%3D&amp;reserved=0\" data-outlook-id=\"1ac43927-7bfd-4593-88f5-4d6a50baf929\">Alcohol as a Modifiable Risk Factor for Alzheimer&#8217;s Disease-Evidence from Experimental Studies<\/a>\u201d which reviewed experimental studies in models where alcohol could influence progression through brain-related mechanisms and alcohol-induced liver injury. Other foundational research includes her lab\u2019s work in examining <a href=\"https:\/\/nam11.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS0969996124001700%3Fvia%253Dihub&amp;data=05%7C02%7Coaconnell%40chapman.edu%7C2b95916a203043b3d2d008dce6eb67f3%7C809929af2d2545bf9837089eb9cfbd01%7C0%7C0%7C638639145939727095%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&amp;sdata=Ai%2FSPVUrdHniAoCFYrlgISU2iEQiiIqdyrMPlJWYFmA%3D&amp;reserved=0\" data-outlook-id=\"a99ea43a-2e8e-4b98-bbe2-22cdfca0d21b\">chronic alcohol consumption in APP\/PS1 models<\/a> with reduced hepatic LRP-1 expression, which also led to increased brain A\u03b2 and behavioral changes, suggesting that hepatic LRP-1 is a critical regulator of brain amyloidosis in alcohol-dependent Alzheimer&#8217;s disease.<\/p>\n<p><em>Pictured above: Dr. Sumbria stands with her research staff, which includes graduate and PharmD students, an undergraduate, and several post-doctorates.\u00a0<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Associate Professor Dr. Rachita Sumbria has been awarded a new R21 grant from the National Institute on Aging (NIA). The [&hellip;]<\/p>\n","protected":false},"author":4726,"featured_media":1984,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"custom_author_name":"","chapman_pin_hero_slider":"","footnotes":""},"categories":[185,405,58,174,28,5,37,53,543],"tags":[2162,2163,2164,2165,2166,2167,2168,1405,2169,2170,1408,2171,2172,1764,1260,115,2173,2174,2175,2176,2177,2178,2179,2180],"class_list":["post-1954","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-awards","category-faculty","category-graduate-programs","category-grants","category-patient-safety","category-pharmacy-school","category-publications","category-research","category-students","tag-alzheimers-and-amyloid-beta","tag-alzheimers-disease-pathology","tag-alzheimers-disease-progression","tag-alzheimers-disease-treatment","tag-alzheimers-research-funding","tag-alzheimers-research-grant","tag-alzheimers-disease-and-obesity","tag-alzheimers-disease-research","tag-amyloid-beta","tag-amyloid-beta-dysregulation","tag-dr-rachita-sumbria","tag-dr-sumbria-research","tag-hepatic-amyloid-beta-dysregulation","tag-national-institute-on-aging","tag-nia","tag-nih-grant","tag-nih-r21-grant","tag-obesity-and-alzheimers","tag-obesity-and-brain-health","tag-obesity-impact-on-alzheimers","tag-obesity-induced-brain-changes","tag-obesity-related-alzheimers","tag-r21-grant","tag-therapeutic-strategies-for-alzheimers"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - 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