{"id":2487,"date":"2025-12-16T11:09:04","date_gmt":"2025-12-16T19:09:04","guid":{"rendered":"https:\/\/blogschapman.wpenginepowered.com\/pharmacy\/2025\/12\/16\/nih-awards-3-million-to-yang-to-advance-care-for-melanoma\/"},"modified":"2025-12-16T11:09:04","modified_gmt":"2025-12-16T19:09:04","slug":"nih-awards-3-million-to-yang-to-advance-care-for-melanoma","status":"publish","type":"post","link":"https:\/\/blogs.chapman.edu\/pharmacy\/2025\/12\/16\/nih-awards-3-million-to-yang-to-advance-care-for-melanoma\/","title":{"rendered":"NIH Awards $3 Million to Yang to Advance Care for Melanoma"},"content":{"rendered":"<p><a href=\"https:\/\/blogs.chapman.edu\/pharmacy\/wp-content\/uploads\/sites\/65\/2025\/12\/coco.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2489 alignleft\" src=\"https:\/\/blogs.chapman.edu\/pharmacy\/wp-content\/uploads\/sites\/65\/2025\/12\/coco.jpeg\" alt=\"\" width=\"248\" height=\"248\" \/><\/a>Sun \u201cCoco\u201d Yang, Ph.D., has been awarded a $3 million 5-year R01 from the National Institutes of Health as Principal Investigator to advance care for melanoma, an aggressive form of skin cancer.<\/p>\n<p>Yang, Associate Professor in the Department of Pharmacy Practice, is a clinical scientist with dual expertise in clinical pharmacy and basic research. In addition to providing direct patient care at City of Hope, her lab at CUSP develops novel treatments for cutaneous melanoma.<\/p>\n<p>\u201cHuman cutaneous melanoma is one of the few cancers in which the incidence rate continues to increase. In 2025, approximately 104,960 new cases of invasive melanoma are expected to be diagnosed in the U.S.,\u201d said Yang. \u201cDespite the recent advances in immune and targeted therapies, the 5-year survival rate of the metastatic disease remains low, at approximately 34.6%.\u201d Many patients fail to respond or eventually develop resistance to existing therapies, creating an urgent need for new treatment options.<\/p>\n<p>Yang\u2019s research team has made significant advancements in understanding the role of neuronal nitric oxide synthase (nNOS) in melanoma development and disease progression. In collaboration with Richard Silverman, Ph.D., at Northwestern University and Jennifer Totonchy, Ph.D. at Chapman University, Yang\u2019s work has yielded key insights into the development of small-molecule inhibitors targeting nNOS with the potential to enhance the anti-tumor activity of immunotherapy for patients diagnosed with melanoma.<\/p>\n<p>The overall goal of their project is to develop novel nNOS inhibitors with improved potency, selectivity, and oral bioavailability. As the PI, Yang is leading a multidisciplinary team in the development of a first-in-class small-molecule nNOS inhibitor for melanoma therapy. The findings have great translational potential, transforming mechanistic insights into novel treatment strategies to improve patient outcomes and advance the fight against this challenging disease.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sun \u201cCoco\u201d Yang, Ph.D., has been awarded a $3 million 5-year R01 from the National Institutes of Health as Principal [&hellip;]<\/p>\n","protected":false},"author":4726,"featured_media":2488,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"custom_author_name":"","chapman_pin_hero_slider":"","footnotes":""},"categories":[185,405,174,53],"tags":[3645,3646,3647,3648,3649,3650,3651,3652,3653,3654,3655,3656,3657,3658,3659],"class_list":["post-2487","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-awards","category-faculty","category-grants","category-research","tag-city-of-hope-melanoma-research","tag-cutaneous-melanoma-treatment-research","tag-melanoma-drug-development","tag-melanoma-immunotherapy-research","tag-melanoma-research-nih-funding","tag-melanoma-therapy-resistance-research","tag-metastatic-melanoma-treatment-innovation","tag-neuronal-nitric-oxide-synthase-inhibitors","tag-nih-r01-melanoma-grant","tag-nih-funded-cancer-research","tag-nnos-melanoma-research","tag-skin-cancer-clinical-research","tag-skin-cancer-research-grant","tag-small-molecule-melanoma-therapy","tag-sun-coco-yang-nih-r01"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - 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