Huntington’s Disease is an autosomal dominant neurodegenerative disease that often is fatal within 10 years after symptoms emerge. There is no known cure as of now, but the cause has been determined. A mutant HTT gene results in a “CAG repeat” that leads to the disease. While not much is known about the gene, there have been theorized solutions to remove it in order to get rid of the disease. In this project we aim to provide a start for the eventual experimental removal of the mutant HTT gene. We obtained C. Elegans to use as our study organism as they have a complex nervous system similar to humans and they are frequently used in transgenic disease studies. We created a behavioral assay for the nematodes in order to quantify behavior and phenotype as we obtained both wild type and mutant C. Elegans, the latter with a human mutant HTT gene. To analyze the genotype, we successfully amplified fragments using a Polymerase Chain Reaction. Overall, this provides for an adequate start for eventually removing the mutant HTT gene to see if the organism is able to become healthy.
On Friday, May 13, 2022, the Grand Challenges Initative (GCI) hosted their annual showcase on the Wilson Ampitheater. GCI Teams presented their projects to their peers, Schmid College community and special guests. Judges evaluated the projects and identified five exceptional teams for recognition: 2022 Arthur C. Flint Prize – CRISPR CRISIS This year’s Arthur C. Flint
This year’s submissions for the 3rd annual Chapman University Grand Challenges Initiative Outstanding Research Publication Award included fascinating results that added to the world’s scientific knowledge in a diverse array of subjects such as the assessment of hazard scales, leaderless mRNAs, and animal cell-size scaling. The articles submitted serve as a testament to Chapman University’s