While the majority of heart arrhythmias have been treated through implantable cardioverter defibrillators (ICD) or orally through medication, many of these treatments have not provided fast-acting relief from an arrhythmia, and have led to malfunctions in sensing of ICD and damage to organs by Amiodarone. Our goal for our project takes a two-pronged approach, which involves an ICD, consisting of a physical treatment of heart arrhythmias, and Drug Delivery, consisting of targeted delivery of amiodarone for biochemical treatment of heart arrhythmias using Poly(propylene imine) Dendrimer. As a group we have accomplished designing a 3D model of our prototype implantable cardioverter defibrillator using CAD, developed procedures to synthesize PPI dendrimers, Au nanoparticles, and a hybrid complex of the two, developed models for PPI dendrimer and Au nanoparticle using Pymol and Fusion 360 respectively, and ran a theoretical comparative study between the effectiveness of drug delivery of PPI dendrimer and beta-cyclodextrin nanoparticles.

Development of an Artificial Implantable Nanoparticle Carrying-Defibrillator Device Poster